How Do Genes Affect How Severe COVID-19 Will Be?

Carlos Bustamante, PhD, professor, Stanford University, Stanford, CA.

David Goldstein, PhD, director, Columbia University Institute for Genomic Medicine.

Jean-Laurent Casanova, MD, PhD, professor, The Rockefeller University, New York City; investigator, Howard Hughes Medical Institute, Chevy Chase, MD.

The Conversation: “Your genes could determine whether the coronavirus puts you in the hospital — and we’re starting to unravel which ones matter.”

GeneCards: “TMPRSS2 Gene.”

Cell: “SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.”

National Center for Biotechnology Information: “Gene ID: ACE2 angiotensin I converting enzyme 2 [ Homo sapiens (human) ].”

Gastroenterology: “IL28B and the Control of Hepatitis C Virus Infection.”

Viruses: “CCR5: From Natural Resistance to a New Anti-HIV Strategy,” “Genetic Susceptibility to Human Norovirus Infection: An Update.”